Advent Tumor Necrosis Factor Alpha (TNF-a) inhibitors represent one a major treatment paradigm for inflammatory diseases. Anti TNF-a drug class one of the most commercially successful drug classes in the pharmaceutical industry worldwide. Currently marketed anti-TNF-a drugs are among the top five global block buster drugs. Cumulative sales of top three TNF-a inhibitors (Remicade, Enbrel, Humira) surpassed $32 billion in 2016.
TNF-a inhibitors exhibit therapeutic efficacy blocking the activity of tumor necrosis factor (TNF), a cytokine that causes inflammation and leads to diverse immune-system diseases. Apparently, almost all the currently marketed TNF-a drugs are indicated for wide spectrum of immune-related disorders such as – Crohn’s disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, plaque psoriasis and uveitis. Advances in biological research is uncovering further therapeutic benefits of this drug class for wider indications. Currently clinical research is focused on evaluating therapeutic efficacy and safety of TNF-a inhibitors on wide range of other inflammatory diseases, neurodegenerative diseases and multiple cancers.
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