Deep Learning & Artificial Intelligence Enhance Live-cell Imaging Techniques - Arizton


The study of proteins, cells, various other processes, and molecular interactions has been transformed by live-cell imaging. Scientists can observe cell structures and processes in real-time and over time using live-cell imaging. The examination of cell structural components, the study of dynamic processes, and the localization of molecules are all possible with live-cell imaging. Live-cell imaging can be used to monitor cellular integrity, endocytosis, exocytosis, protein trafficking, signal transduction, and enzyme activity. The most significant change in the field of Live-cell imaging has been the development of newer imaging techniques, which has resulted in the ability to obtain images with many more types of samples and higher resolution. Light sheet fluorescence microscopy, for example, was created to allow researchers to see through transparent samples such as zebrafish. The technique also allows you to focus on the parts of the organisms without worrying about stray light from other parts of the sample. The increased accessibility of multiphoton microscopy, which can be used to examine animal brains, is also a game changer. 

AI-based self-learning microscopy has the potential to make high-throughput image analysis easier and less time-consuming. In the past, the power of microscopy to support or disprove scientific hypotheses was limited by scale, and the time required to capture, quantify, and analyze large numbers of images was often prohibitive. HCS stations increase the scale of experiments. More recently, the advent of deep-learning-based AI has enabled the same leap forward in the analysis phase of a study. Newer AI technology allows the visualization of unlabeled living cells over a prolonged duration, thereby enabling the study of cell viability and pathology and providing a clear picture of various mechanisms. Facial-recognition AI technology helps identify and track individual cells in complex systems, such as tissues. 

In live-cell imaging, the challenge of AI-based approaches is not just to detect cells but also to retrieve information from each cell without any human input. AI can significantly streamline the data analysis process by overcoming these challenges. 

Moreover, Live cellular analysis is done to evaluate and measure the present state of cells, such as cell integrity, viability, toxicity, and other research applications. A fundamental part of cell analysis is data collection, analysis, and export into a meaningful and useful format. Applications of cell analyzers range from proliferation assays to immune killing of tumor spheroids, enabling users to observe and quantify complex biological changes. Some major analysis systems are Sartorius AG, Incucyte SX5 Live-Cell Analysis Systems, Incucyte S3 Live-Cell Analysis System, and the Incucyte SX1 Live-Cell Analysis System. 


Key Competitors Insights  

Danaher: Danaher is a global science and technology innovation company committed to help its customers solve complex challenges and improve the quality of life globally. Danaher is a leading company in the global live-cell imaging market with the acquisition of Leica Microsystems and Molecular Devices. It provides a wide range of microscopy systems to study live cells. 

Agilent Technologies: Agilent is a leading company in diagnostics, life sciences, and applied chemical markets. The company offers instruments, consumables, services, applications, and expertise to laboratories worldwide. The company provides up to 100x magnification, plus brightfield, color brightfield, phase contrast and fluorescence channels, and Lionheart Automated Microscopes support a wide range of microscopy workflows. 

PerkinElmer: PerkinElmer's dedicated live-cell imaging system called the MuviCyte fits inside an incubator and enables long-term observations for several days or weeks under optimal conditions. Its HCS systems, Opera Phenix Plus and Operetta CLS, help run live-cell assays and observe live cells over time with the quantitative, multiparametric data analysis needed in drug discovery programs. 

Merck KGaA: Merck KGaA offers best-in-class pharmaceutical development and manufacturing of products and a fully integrated service organization to support contract testing. Its portfolio of live-cell imaging reagents includes novel fluorescent cell labeling technologies for cell tracking, fluorescent lentiviral biosensors, traditional fluorescent dyes, and probes to analyze cellular events in real-time. 

ZEISS: ZEISS Microscopy is the world's only one-stop manufacturer of light, X-ray, electron, and ion microscopy systems and offers correlative microscopy solutions. Its portfolio comprises products and services for life sciences, industrial and material research, and clinical practice and education. 

Thermo Fisher Scientific: Thermo Fisher Scientific offers Invitrogen reagents recognized worldwide as key components for publication-quality cellular images and analysis. It combines powerful Invitrogen imaging and detection reagents with EVOS Cell Imaging Systems, Thermo Scientific Microplate Readers, and CellInsight High Content Analysis platforms. 

Recent Developments in Global Live-cell imaging Market 

  • In 2021, CytoSMART Technologies launched the CytoSMART Lux3 BR, a new type of brightfield microscope. It is a live-cell imaging microscope with a high-quality complementary metal oxide semiconductor (CMOS) camera to assist label-free cell imaging procedures. 
  • In 2021, the Zeiss Group announced the launch of its Zeiss Visioner 1, a Zeiss live-cell imaging system and innovative digital microscope that facilitates real-time, all-in-one focus through a micro-mirror array system. 
  • In 2020, CytoSMART Technologies launched the CytoSMART Multi Lux, a remote live-cell imaging system. 
  • In 2020, Etaluma partnered with innoME GmbH to introduce entry-level incubator cell imaging to the Americas.  

Large vendors dominate the market and witness high competition from regional and local companies from the UK, Italy, China, India, and South Korea. Many regional companies also invest in new therapy products in Europe, APAC, and North America. These companies also pose a threat to global players due to their innovative and cost-effective technologies. This indicates that the global live-cell imaging market offers enormous growth opportunities to existing and future or emerging players. This is supported by a large pool of target patient populations with chronic diseases and the demand for drug discovery studies. 

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