EXHIBIT 1 SEGMENTATION OF SOUTH AFRICA BIOPHARMACEUTICALS MARKET
EXHIBIT 2 MARKET SIZE CALCULATION APPROACH 2022
EXHIBIT 3 SOUTH AFRICA BIOPHARMACEUTICALS MARKET BY PRODUCT: MARKET SHARE 2022 & 2028 (%)
EXHIBIT 4 SOUTH AFRICA BIOPHARMACEUTICALS MARKET BY THERAPY AREA: MARKET SHARE 2022 & 2028 (%)
EXHIBIT 5 GLOBAL BIOPHARMACEUTICALS MARKET 2022–2028 ($ BILLION)
EXHIBIT 6 SUMMARY OF THE BIOLOGICAL MEDICINES EVALUATION AND RESEARCH UNIT (BMERU) REGULATORY REQUIREMENTS FOR BIOLOGIC & BIOSIMILAR COMPOUNDS IN SOUTH AFRICA
EXHIBIT 7 COMPARISON OF REQUIREMENTS FOR REGISTRATION OF A BIOSIMILAR & REFERENCE MEDICINAL PRODUCT
EXHIBIT 8 IMPACT OF PROMISING SIGNS FOR LOCAL BIOPHARMACEUTICAL PRODUCTION IN SOUTH AFRICA
EXHIBIT 9 IMPACT OF INCREASED ADOPTION OF BIOSIMILARS
EXHIBIT 10 IMPACT OF GROWTH OF PHARMACEUTICAL INDUSTRY & INVESTMENT OPPORTUNITIES
EXHIBIT 11 IMPACT OF INCREASED ACCESS TO CGT IN SOUTH AFRICA
EXHIBIT 12 IMPACT OF PREVALENCE OF CHRONIC DISEASES & LARGE AGING POPULATION
EXHIBIT 13 IMPACT OF INCREASED FOCUS ON PRECISION MEDICINE
EXHIBIT 14 IMPACT OF BIOLOGICS UPTAKE & POTENTIAL IN SOUTH AFRICA
EXHIBIT 15 IMPACT OF LACK OF MANUFACTURING CAPABILITIES
EXHIBIT 16 IMPACT OF HIGH DEVELOPMENT COST OF BIOLOGICS
EXHIBIT 17 IMPACT OF POOR PATIENT ACCEPTANCE & ACCESS TO BIOLOGICS
EXHIBIT 18 SOUTH AFRICA BIOPHARMACEUTICALS MARKET 2022–2028 ($ MILLION)
EXHIBIT 19 SOUTH AFRICA BIOPHARMACEUTICALS MARKET BY PRODUCT: MARKET OPPORTUNITY OVERVIEW
EXHIBIT 20 SOUTH AFRICA BIOPHARMACEUTICALS MARKET BY THERAPY AREA: MARKET OPPORTUNITY OVERVIEW
EXHIBIT 21 FIVE FORCES ANALYSIS 2022
EXHIBIT 22 INCREMENTAL GROWTH BY PRODUCT 2022 & 2028
EXHIBIT 23 SOUTH AFRICA BIOPHARMACEUTICALS MARKET BY PRODUCT 2022–2028: INCREMENTAL GROWTH ($ MILLION)
EXHIBIT 24 SOUTH AFRICA BIOPHARMACEUTICALS MARKET BY PRODUCT 2022–2028: ABSOLUTE GROWTH (%)
EXHIBIT 25 SOUTH AFRICA VACCINES MARKET 2022–2028: INCREMENTAL & ABSOLUTE GROWTH
EXHIBIT 26 SOUTH AFRICA VACCINES MARKET 2022–2028 ($ MILLION)
EXHIBIT 27 SOUTH AFRICA MONOCLONAL ANTIBODIES MARKET 2022–2028: INCREMENTAL & ABSOLUTE GROWTH
EXHIBIT 28 SOUTH AFRICA MONOCLONAL ANTIBODIES MARKET 2022–2028 ($ MILLION)
EXHIBIT 29 SOUTH AFRICA RECOMBINANT PROTEINS & HORMONES MARKET 2022–2028: INCREMENTAL & ABSOLUTE GROWTH
EXHIBIT 30 SOUTH AFRICA RECOMBINANT PROTEINS & HORMONES MARKET 2022–2028 ($ MILLION)
EXHIBIT 31 SOUTH AFRICA TISSUE, CELL & GENE THERAPIES MARKET 2022–2028: INCREMENTAL & ABSOLUTE GROWTH
EXHIBIT 32 SOUTH AFRICA TISSUE, CELL & GENE THERAPIES MARKET 2022–2028 ($ MILLION)
EXHIBIT 33 INCREMENTAL GROWTH BY THERAPY AREA 2022 & 2028
EXHIBIT 34 SOUTH AFRICA BIOPHARMACEUTICALS MARKET BY THERAPY AREA 2022–2028: INCREMENTAL GROWTH ($ MILLION)
EXHIBIT 35 SOUTH AFRICA BIOPHARMACEUTICALS MARKET BY THERAPY AREA 2022–2028: ABSOLUTE GROWTH (%)
EXHIBIT 36 SOUTH AFRICA INFECTIOUS DISEASES BIOPHARMACEUTICALS MARKET 2022–2028: INCREMENTAL & ABSOLUTE GROWTH
EXHIBIT 37 SOUTH AFRICA INFECTIOUS DISEASES BIOPHARMACEUTICALS MARKET 2022–2028 ($ MILLION)
EXHIBIT 38 SOUTH AFRICA DIABETES BIOPHARMACEUTICALS MARKET 2022–2028: INCREMENTAL & ABSOLUTE GROWTH
EXHIBIT 39 SOUTH AFRICA DIABETES BIOPHARMACEUTICALS MARKET 2022–2028 ($ MILLION)
EXHIBIT 40 SOUTH AFRICA ONCOLOGY BIOPHARMACEUTICALS MARKET 2022–2028: INCREMENTAL & ABSOLUTE GROWTH
EXHIBIT 41 SOUTH AFRICA ONCOLOGY BIOPHARMACEUTICALS MARKET 2022–2028 ($ MILLION)
EXHIBIT 42 SOUTH AFRICA INFLAMMATION & IMMUNOLOGY BIOPHARMACEUTICALS MARKET 2022–2028: INCREMENTAL & ABSOLUTE GROWTH
EXHIBIT 43 SOUTH AFRICA INFLAMMATION & IMMUNOLOGY BIOPHARMACEUTICALS MARKET 2022–2028 ($ MILLION)
EXHIBIT 44 SOUTH AFRICA OTHER THERAPY AREAS BIOPHARMACEUTICALS MARKET 2022–2028: INCREMENTAL & ABSOLUTE GROWTH
EXHIBIT 45 SOUTH AFRICA OTHER THERAPY AREAS BIOPHARMACEUTICALS MARKET 2022–2028 ($ MILLION)
EXHIBIT 46 VENDORS THAT OFFER COMMERCIAL BIOPHARMACEUTICALS: MARKET DOMINANCE ANALYSIS
EXHIBIT 47 VENDORS THAT OFFER COMMERCIAL BIOPHARMACEUTICALS: CAPABILITIES & EXPERTISE ASSESSMENT
EXHIBIT 48 ABBVIE: TOTAL REVENUE 2020–2022 ($ BILLION)
EXHIBIT 49 ABBVIE: R&D EXPENDITURE 2020–2022 ($ BILLION)
EXHIBIT 50 F. HOFFMANN-LA ROCHE: TOTAL REVENUE 2020–2022 ($ BILLION)
EXHIBIT 51 F. HOFFMANN-LA ROCHE: R&D EXPENDITURE 2020–2022 ($ BILLION)
EXHIBIT 52 F. HOFFMANN-LA ROCHE: REVENUE BY BUSINESS SEGMENT 2022 ($ BILLION)
EXHIBIT 53 GSK: TOTAL REVENUE 2020–2022 ($ BILLION)
EXHIBIT 54 GSK: R&D EXPENDITURE 2020–2022 ($ BILLION)
EXHIBIT 55 JOHNSON & JOHNSON: TOTAL REVENUE 2020–2022 ($ BILLION)
EXHIBIT 56 JOHNSON & JOHNSON: R&D EXPENDITURE 2020–2022 ($ BILLION)
EXHIBIT 57 JOHNSON & JOHNSON: REVENUE BY BUSINESS SEGMENT 2022 ($ BILLION)
EXHIBIT 58 JOHNSON & JOHNSON: REVENUE BY GEOGRAPHIC REGION 2022 ($ BILLION)
EXHIBIT 59 MERCK & CO.: TOTAL REVENUE 2020–2022 ($ BILLION)
EXHIBIT 60 MERCK & CO.: R&D EXPENDITURE 2020–2022 ($ BILLION)
EXHIBIT 61 MERCK & CO.: REVENUE BY BUSINESS SEGMENT 2022 ($ BILLION)
EXHIBIT 62 MERCK & CO.: REVENUE BY GEOGRAPHIC REGION 2022 ($ BILLION)
EXHIBIT 63 NOVARTIS: TOTAL REVENUE 2020–2022 ($ BILLION)
EXHIBIT 64 NOVARTIS: R&D EXPENDITURE 2020–2022 ($ BILLION)
EXHIBIT 65 NOVARTIS: REVENUE BY BUSINESS SEGMENT 2022 ($ BILLION)
EXHIBIT 66 NOVARTIS: REVENUE BY GEOGRAPHY 2022 ($ BILLION)
EXHIBIT 67 NOVO NORDISK: TOTAL REVENUE 2020–2022 ($ BILLION)
EXHIBIT 68 NOVO NORDISK: R&D EXPENDITURE 2020–2022 ($ BILLION)
EXHIBIT 69 PFIZER: TOTAL REVENUE 2020–2022 ($ BILLION)
EXHIBIT 70 PFIZER: R&D EXPENDITURE 2020–2022 ($ BILLION)
EXHIBIT 71 PFIZER: REVENUE BY BUSINESS SEGMENT 2021 ($ BILLION)
EXHIBIT 72 PFIZER: REVENUE BY GEOGRAPHIC REGION 2021 ($ BILLION)
EXHIBIT 73 SANOFI: TOTAL REVENUE 2020–2022 ($ BILLION)
EXHIBIT 74 SANOFI: R&D EXPENDITURE 2020–2022 ($ BILLION)
EXHIBIT 75 SANOFI: REVENUE BY BUSINESS SEGMENT 2022 ($ BILLION)
EXHIBIT 76 SANOFI: REVENUE BY GEOGRAPHIC REGION 2022 ($ BILLION)
LIST OF TABLES
TABLE 1 KEY CAVEATS
TABLE 2 CURRENCY CONVERSION 2016–2022
TABLE 3 SOUTH AFRICA: OVERVIEW
TABLE 4 SUMMARY OF CROSS-COUNTRY ANALYSIS
TABLE 5 EFFECTS OF BIOSIMILAR LAUNCH ON ORIGINATOR STANDARD UNIT PRICE IN SOUTH AFRICA USING AVERAGE PRICE PER MOLECULE
TABLE 6 SOUTH AFRICA BIOPHARMACEUTICALS MARKET BY PRODUCT: MARKET SIZE 2022 & 2028 ($ MILLION)
TABLE 7 SOUTH AFRICA BIOPHARMACEUTICALS MARKET BY THERAPY AREA: MARKET SIZE 2022 & 2028 ($ MILLION)
TABLE 8 MABS APPROVED IN SOUTH AFRICA
TABLE 9 ABBVIE: MAJOR PRODUCT OFFERINGS
TABLE 10 F. HOFFMANN-LA ROCHE: MAJOR PRODUCT OFFERINGS
TABLE 11 GSK: MAJOR PRODUCT OFFERINGS
TABLE 12 JOHNSON & JOHNSON: MAJOR PRODUCT OFFERINGS
TABLE 13 MERCK & CO.: MAJOR PRODUCT OFFERINGS
TABLE 14 NOVARTIS: MAJOR PRODUCT OFFERINGS
TABLE 15 NOVO NORDISK: MAJOR PRODUCT OFFERINGS
TABLE 16 PFIZER: MAJOR PRODUCT OFFERINGS
TABLE 17 SANOFI: MAJOR PRODUCT OFFERINGS
TABLE 18 AMGEN: MAJOR PRODUCT OFFERINGS
TABLE 19 BIOCON: MAJOR PRODUCT OFFERINGS
TABLE 20 BIOGEN: MAJOR PRODUCT OFFERINGS
TABLE 21 CIPLA: MAJOR PRODUCT OFFERINGS
TABLE 22 ELI LILLY AND COMPANY: MAJOR PRODUCT OFFERINGS
TABLE 23 TEVA PHARMACEUTICAL INDUSTRIES: MAJOR PRODUCT OFFERINGS
TABLE 24 VIATRIS: MAJOR PRODUCT OFFERINGS
TABLE 25 SOUTH AFRICA BIOPHARMACEUTICALS MARKET BY PRODUCT 2022–2028 ($ BILLION)
TABLE 26 SOUTH AFRICA BIOPHARMACEUTICALS MARKET BY PRODUCT 2022–2028 (%)
TABLE 27 SOUTH AFRICA BIOPHARMACEUTICALS MARKET BY THERAPY AREA 2022–2028 ($ BILLION)
TABLE 28 SOUTH AFRICA BIOPHARMACEUTICALS MARKET BY THERAPY AREA 2022–2028 (%)